Kumar and Clark's Clinical Medicine, 7th Edition (MRCP Study Guides)

• Publisher:   Saunders Ltd.
• Number Of Pages:   1360
• Publication Date:   2009-07-17
• ISBN-10 / ASIN:   0702029939
• ISBN-13 / EAN:   9780702029936

Product Description:

The 7th edition of Kumar and Clark's Clinical Medicine is a thoroughly updated, reworked and revised new edition of the first-prize winner in the Medicine category in the BMA 2006 Medical Book Competition. It is the market-leading comprehensive and authoritative single-volume textbook of internal medicine, consulted by students and doctors alike throughout the world. Covering the management of disease, based on an understanding of scientific principles, and including the latest developments in treatment, it is written for medical students and doctors preparing for specialist exams, but it is an ideal general reference text for all practising doctors. The new edition is part of Elsevier's StudentConsult electronic community. StudentConsult titles come with full text online, a unique image library, case studies, questions and answers, online note-taking, and integration links to content in other disciplines - ideal for problem-based learning.

Download

Read More

Nanocosmetics and Nanomedicines: New Approaches for Skin Care

The book "Nanocosmetics and nanomedicines: new approaches for skin care contains a summary of the most important nanocarriers for skin delivery. Although Snanocosmetics is a subject widely commented in the academy and the beauty industry, a book covering the skin care treatments using nanotechnological approaches with cosmetics and nanomedicines is still missing, therefore the need for this publication. This book is divided in three parts: The first one (Part A) is devoted to a brief review on the main topics related to the skin delivery and to the introduction of the subject Snanocosmetics . The second part (Part B) presents different types of nanocarriers applied as skin delivery systems for cosmetics or drugs. The last part (Part C) shows a wide range of applications of nanotechnology on the skin care area as well as on dermatocosmetic and dermatological fields.
Cover

Nanocosmetics and Nanomedicines

ISBN 9783642197918

Forword

Contents

Part I Fundamentals of Skin Delivery

     1 Transport of Substances and Nanoparticles across the Skin and in Vitro Models to Evaluate Skin Permeation and/or Penetration

          Introduction

          Transport across the Skin

          In Vitro Models and Membranes Used to Evaluate Skin Permeation and/or Penetration

               In Vitro Diffusion Models

               Microscopy Techniques

               Membranes

          Transport of Nanoparticles and Encapsulated Substances across the Skin

               Nanoparticles Based on Organic Compounds

               Nanoparticles Based on Inorganic Compounds

          Concluding Remarks

          References

     2 Rheological Behavior of Semisolid Formulations Containing Nanostructured Systems

          Introduction

          Rheology: Fundamental Concepts

          Rheological Properties of Nanoparticles Incorporated into Semisolids

          Conclusions

          References

Part II Nanocarriers for Skin Care and Dermatological Treatments

     3 Polymeric Nanocapsules: Concepts and Applications

          Introduction

          Models of the Supramolecular Structure of Nanocapsules

               Core

               Surface

          Nanocapsule Preparation

               Chemical Methods

               Physicochemical Methods

          Methods of Physicochemical Characterization

          Nanocapsules in Skin Formulations: Advantages and Challenges

          Concluding Remarks

          References

     4 Topical Application of Nanostructures: Solid Lipid, Polymeric and Metallic Nanoparticles

          Introduction

          Preparation and Characterization of Solid Lipid Nanoparticles (SLN)

               Hot Microemulsion

               Emulsification and Solvent Evaporation

               Solvent Diffusion Method

               High Pressure Homogenization (HPH) Method

               X-Ray Diffraction

               Differential Scanning Calorimetry (DSC)

               Proton Nuclear Magnetic Resonance (NMR)

               Microscopy Techniques

          Preparation and Characterization of Polymeric Nanoparticles

               Encapsulation Efficiency

               Dynamic Light Scattering (DLS)

               Microscopic Techniques

               In Vitro Drug Release

               Differential Scanning Calorimetry (DSC) and Other Molecular-Level Methods

          Preparation and Characterization of Metallic Nanoparticles

          Topical Application of SLN, and Polymeric and Silver Nanoparticles

               SLN Application

               Polymeric Nanoparticles

               Metallic Nanoparticles

          Future Perspectives

          References

     5 Lipid Nanoparticles as Carriers for Cosmetic Ingredients: The First (SLN) and the Second Generation (NLC)

          Introduction

          Nanocarriers and Skin Interaction

          Definitions

               Lipid Nanoparticles

               Solid Lipid Nanoparticles (SLN)

               Nanostructured Lipid Carriers (NLC)

          Preparation of Lipid Nanoparticles

          Characterization of Lipid Nanoparticles

               Particle Size Distribution

               Zeta Potential

               Physical Stability Kinetics

               Crystal Structure

               Morphological Aspects

          Loading Capacity and Active Agent Incorporation Mechanisms

          Modulation of Active Agent Release

          Recent Advances and Advantages of SLN and NLC for Cosmetic Applications

               Formulations and Products

               Encapsulation as a Protective Tool

               The Occlusion Effect

               The UV Blocking Effect

          Conclusions and Future Perspectives

          References

     6 Industrial Production of Polymeric Nanoparticles: Alternatives and Economic Analysis

          Introduction

          Alternatives Proposal

          Definitions

               Investment Cost

               Production Cost

               Basic Concepts

          Methodology

          Analysis of Economic Viability

               Production of 10 kg/day

               Production of 20 kg/day

          Sensitivity Analysis of Sale Price vs. Production

          Conclusions

          References

     7 Elastic Liposomes

          Introduction

          State-of-Art Technologies

          Elastic Liposomes Systems

               Conventional Liposomes

               Elastic Liposomes

               Membrane Elasticity

               Mechanisms

          Characterization Methods

               Transdermal Transport of Liposomes

          Final Remarks

          References

     8 Chitosan as Stabilizer and Carrier of Natural Based Nanostructures

          Introduction

          Chitosan as Stabilizer of Nanostructures

          Chitosan as Carrier of Natural Based Nanostructures

          Concluding Remarks

          References

Part III Applications of Nanocosmetics and Nanomedicines for Skin Treatments

     9 Performance of Elastic Liposomes for Topical Treatment of Cutaneous Leishmaniasis

          Introduction

               Cutaneous Leishmaniasis

               Chemotherapy

               Topical Treatment of CL

               Liposomes for Topical Treatment of CL

          Preparation of Elastic Liposomes Loaded with Chalcone CH8

               CH8- Loaded Conventional Liposomes (CH8-CvL)

               CH8- Loaded Pegylated Liposomes (CH8-PL)

          CH8-Loaded Liposome Characterization

               Size Distribution

               Morphology

               Phospholipids Concentration

               Elasticity

          Biological Assessments of the CH8-Loaded Liposomes

               In Vitro Skin Permeation

               Topical Efficacy against Murine CL

          Conclusion

          Future Perspectives

          References

     10 Druggable Targets for Skin Photoaging: Potential Application of Nanocosmetics and Nanomedicine

          Skin Phototoxicity

               Acute Effects of UV on Skin

               Chronic Effects of UV on Skin

          In Vitro Index of Phototoxicity

               Photo-Irritation Factor

          Molecular Markers of Skin Inflammation, Senescence and Photoaging

               Molecular Markers of Inflammation

               Molecular Marker of Senescence

          Nanocosmetics and Nanomedicine for Overcoming Skin Photoaging

               Photoprotection

          Molecular Action of the Toxicity of Carbon Nanotubes in Skin Cells

          Final Remarks

          References

     11 Nanomedicine: Potential Killing of Cancercells Using Nanoparticles

          General Introduction

          Apoptosis

          Apoptosis Cell Death: Biochemistry and Molecular Aspects

          Cell Death by Apoptosis Signaling

          Cell Death and Cancer

          Nanomedicine for the Management of Cancer Cells

               Polymeric Nanoparticles

               Silver Nanoparticles

          Future Perspectives

          References

     12 Zebrafish as a Suitable Model for Evaluating Nanocosmetics and Nanomedicines

          Introduction

          Biology of Zebrafish

          Zebrafish as a Correlative and Predictive Model for Measuring Biomaterial Nanotoxicity

          Screening of Skin Care Products Based on Zebrafish Development

          Future Perspectives

          References

     13 Nitric Oxide-Releasing Nanomaterials and Skin Care

          Nitric Oxide and Skin: Current Status

          The Role of NO in Physiologic Responses in the Skin

          NO and Skin Diseases

          NO and Wound Healing

          Nanotechnology and NO in Skin Treatments

          NO and Skin Pigmentation Enhancers

          Future Directions and Challenges in Dermatological Therapeutics

          References

     14 Nanocarriers and Cancer Therapy: Approaches to Topical and Transdermal Delivery

          Nanotechnology in Healthcare: Evolution

          Technological Advances: Nanotechnology and Cancer

          New Strategies for Topical and Transdermal Treatment of Cancer

               Target Delivery

               Chemical and Formulation Enhancers of Skin Penetration and Permeation

               Physical Methods: Iontophoresis, Sonophoresis, and Electroporation

               Microneedles

          Final Considerations

          References

     15 Nanocarriers to Deliver Photosensitizers in Topical Photodynamic Therapy and Photodiagnostics

          Topical Photodynamic Therapy

               General Considerations

               Skin Cancer and Non-neoplastic Disorders

               Photosensitizers and Precursors

          Skin as Administration Site for Topical PDT

               Skin Structure, Barrier and Permeability

               Drug Delivery Systems in Topical PDT

          Future Directives

          References

     16 Production of Nanofibers by Electrospinning Technology: Overview and Application in Cosmetics

          Overview

               Introduction

               History of Nanofibers Obtained by Electrospinning

          Preparation of Nanofiber by Electrospinning Technology

               Polymers Used in the Electrospinning Process

               Electrospinning Process Control Parameters

          Characterization of Electrospun Nanofibers

          Application of Polymer Nanofibers

          Application of Polymeric Nanofibers in Cosmetics

          Future Perspectives of Nanofibers by Electrospinning in Cosmetic Application

          References

     17 Nanosized and Nanoencapsulated Sunscreens

          Introduction

          Nanosized UV Filters

               TiO2 and ZnO-Induced Cytotoxicity and Genotoxicity

               Skin Penetration

               Novel nanosized UV filters

          Nanoencapsulated UV Filters

               Skin Penetration

               Photostability

               UV-Blocking Ability

          Nanoparticles in Sunscreens Today: The Commercial Arena

          Conclusions

          References

About the Editors

Subject Index

CnGTVL5r3VMC

Download

OR

Read More

Business Marketing: Connecting Strategy, Relationships, and Learning

F. Robert Dwyer, John F Tanner, John Tanner, "Business Marketing: Connecting Strategy, Relationships, and Learning"
McG-aw-H-ll/Ir-n | 2001-07-13 | ISBN 0072410639 | PDF | 736 pages | 6,4 MB

This text is targeted at the undergraduate Business Marketing course. It introduces the concepts of marketing to businesses and stresses the importance of building relationships with customers.
The book very interesting as in the book all is very detailed is written. In this book it is a lot of interesting. The book very fascinating, informative, simply interesting to reading. Any person can download the book.

Download

OR

Read More

The Ultimate Guide to Finding the Right Job After Residency

Koushik Shaw, "The Ultimate Guide to Finding the Right Job After Residency"
MgH | 2005 | ISBN: 0071461132 | 304 pages | PDF | 1,1 MB

This is a one-of-a-kind single source compendium of employment advice for residents looking for their first job and physicians looking to make career changes. For the first time, important issues such as geographic considerations, partnerships, salaries, legalities, starting an effective job search, interviewing tips, contract negotiation, are all discussed in detail by someone who's been there and lived it.

Download

OR

Read More

Guerrilla Marketing for Job Hunters: 400 Unconventional Tips, Tricks, and Tactics for Landing Your Dream Job

Jay Conrad Levinson, "Guerrilla Marketing for Job Hunters: 400 Unconventional Tips, Tricks, and Tactics for Landing Your Dream Job"
Wi-y | 2005 | ISBN: 0471714844 | 288 pages | PDF | 6,8 MB

"This is an immensely helpful book, with the ancient wisdom of recruiters,?and the up-to-date?insights of two skilled Internet surfers. If you're job-hunting, you'll be grateful to learn the tips and tricks of these two seasoned veterans. I learned a lot myself."
—Richard N. Bolles, author, What Color Is Your Parachute?

"I have been an apprentice, a company president, and a CEO. No other single source provides a more contemporary and embracing job search bible. This book offers literally hundreds of little known insider tips, strategies, out-of-the-box success stories, hands-on exercises, and pearls of wisdom. Many readers will hear the words, 'You're Hired' due to David Perry and Guerrilla Marketing for Job Hunters."
—Kelly Perdew, Executive Vice President, Trump Ice winner of The Apprentice 2

"Guerrilla Marketing for Job Hunters is an absolutely 'right on' book for today's job market. It not only has great job search tips but it takes you into the electronic job search system better than anything I've seen written to date."
—William J. Morin, Chairman and CEO, WJM Associates, Inc. former CEO of DBM

Using a typically unconventional Guerrilla approach, authors Levinson and Perry cover all the basics of a winning campaign. This book covers:

* Using the Internet for everything from research and job searches to your own Web site, blogs, and podcasting
* Performing an extreme resume makeover and creating a higher-powered value-based resume
* Harnessing the full power of Google, LinkedIn, and ZoomInfo to uncover opportunities in the "hidden job market" ahead of your competition (or other job hunters)
* Branding yourself and selling your strengths in resumes, letters, e-mail, and interviews

Guerrilla Marketing for Job Hunters includes real-life war stories from successful job hunters and expert tips and tactics from over 100 prominent headhunters.

Download

OR

Read More

The Million Dollar Sale: How to Get to the Top Decision Makers and Close the Big Sale

The Million Dollar Sale: How to Get to the Top Decision Makers and Close the Big Sale
Publisher: McGraw-Hill; 1 edition (September 16, 2004) | ISBN: 0071445196 | Pages: 179 | PDF | 5,42 MB

How to reach the real decision makers and close the all-important sale.
How do today's most successful sales professionals close multimillion-dollar deals? They do it by teaming up with "Codebreakers"-- sales reps from non-competing firms already doing millions of dollars of business with target clients.
In The Million Dollar Sale, sales guru Patricia Gardner Explains how to find Codebreakers, gain their interest, and persuade them to form powerful selling alliances and describes how her Codebreaker system closed multimillion-dollar deals at Johnson & Johnson, Verizon, Goodyear, Xerox, and other top companies.

Download

OR

Read More

Job Hunting Guide: Transitioning From College to Career

Job Hunting Guide: Transitioning From College to Career by Ron & Caryl Krannich
Publisher: Impact Publications | 2003-02-25 | ISBN: 1570231885 | PDF | 198 pages | 16 MB

Today's college students face a challenging job market requiring greater attention to job search basics. A new book, written in collaboration with students, employers, and university administrators, provides sound advice on how to best find and keep jobs. What happens when two of America's leading career writers join the top online employment site for college students? They produce a unique job search book designed to assist college students and recent grads in finding jobs and launching new careers. Recognizing the realities of student job hunting - often lacking time, focus, and structure - the authors outline a step-by-step process for finding the perfect job within 90 days.

Authors of more than 35 career books, Ron and Caryl Krannich, Ph.Ds., have teamed up with CampusCareerCenter.com to produce the definitive guide to today's turbulent employment market. Former university professors and career advisors to millions of readers, the Krannichs draw on their many years of career planning experience as well as an active community of students, employers, and university administrators who participate in the popular CampusCareerCenter.com website.
The book begins with a pre-test of readers' knowledge, skills, and behaviors for job search success - "What's Your Hiring I.Q.?" - that sets the stage for the remainder of the book. Outlining a seven-step sequential job search model, the authors detail the most important aspects of the job search, including a rich collection of relevant examples and exercises: skills assessment, goal setting, research, resume and letter writing, networking, interviewing, and salary negotiations. Recognizing both the interpersonal and electronic nature of the job search, the authors carefully integrate the use of the Internet into a traditional face-to-face job search by revealing numerous helpful websites for enhancing each job search step. A special chapter on getting started on the new job includes observations of recent graduates who share lessons learned about their new work world. A resource-rich chapter focuses on three employment arenas of keen interest to college students: government, nonprofit, and international. A final chapter profiles 53 employers who regularly recruit college students and graduates for internships and part-time and full-time positions. Throughout the book several college career counselors give advice on what works best in the job-finding trenches for college students and recent graduates.
Filled with cutting-edge strategies, tips, self-assessment exercises, and advice from students, employers, and counselors, here's the ultimate college transition book. It speaks directly to students about what they need to do to quickly find a good job that leads to a career compatible with their unique mix of interests, skills, and abilities. The book no student should leave college without!

 

Download

OR

 

Read More